His group develops materials for application in biological environments, characterising relationships between the surface and biological response. Understanding these relationships is critical in the development of the biomaterials of the future and is the theme running through his group's work across a variety of biomedical application areas spanning bacterial adhesion to controlling stem cell response.
Much progress has been made in discovering new biomaterials using a high throughput materials screening approach. He has contributed to books on surface chemical modification and analysis and has authored over papers dealing with surfaces in high quality peer reviewed publications, including research articles in Nature Biotechnology, Nature Materials, Nature Methods, Nature Communications, Advanced Materials, PNAS and Biomaterials.
This research is highly interdisciplinary, involving collaborators from a wide variety of fields including regenerative medicine, neuroscience, developmental biology, pharmaceutics, materials processing, plasma physics and nanofabrication, in the UK and with leading groups around the world, eg MIT and La Trobe.
A number of his group have gone on to take up independent research posts. Publications and metrics here. For all enquiries please visit: www. Connect with the University of Nottingham through social media and our blogs.
Campus maps More contact information Jobs. Discovery of meth acrylate polymers that resist colonization by fungi associated with pathogenesis and biodeterioration. Science Advances. Advanced Materials. Fellow of the Royal Society of Chemistry High-throughput characterization of fluid properties to predict droplet ejection for three-dimensional inkjet printing formulations Additive Manufacturing. ZHOU, Z. High-throughput characterization of fluid properties to predict droplet ejection for three-dimensional inkjet printing formulations: Additive Manufacturing Additive Manufacturing.
Methodology for the synthesis of methacrylate monomers using designed single mode microwave applicators: Reaction Chemistry and Engineering Reaction Chemistry and Engineering. In Press. Dual bioresponsive antibiotic and quorum sensing inhibitor combination nanoparticles for treatment of Pseudomonas aeruginosa biofilms in vitro and ex vivo. Biomaterials science. Improved extraction repeatability and spectral reproducibility for liquid extraction surface analysis — mass spectrometry using superhydrophobic-superhydrophilic patterning Analytical Chemistry.
Bioprinting using mechanically robust core-shell cell-laden hydrogel strands, Macromolecular Bioscience. Image based Machine Learning for identification of macrophage subsets. Scientific reports. International journal of pharmaceutics. Journal of controlled release : official journal of the Controlled Release Society. Development and characterization of a stable adhesive bond between a poly dimethylsiloxane catheter material and a bacterial biofilm resistant acrylate polymer coating Biointerphases.
HOOK, A. Engineering serendipity: High-throughput discovery of materials that resist bacterial attachment: Acta Biomaterialia Acta Biomaterialia. The impact of surface chemistry modification on macrophage polarisation. The influence of nanotexturing of poly lactic-co-glycolic acid films upon human ovarian cancer cell attachment. A defined synthetic substrate for serum-free culture of human stem cell derived cardiomyocytes with improved functional maturity identified using combinatorial materials microarrays Biomaterials.
Revealing cytokine-induced changes in the extracellular matrix with secondary ion mass spectrometry Acta Biomaterialia.
Bacterial attachment to polymeric materials correlates with molecular flexibility and hydrophilicity Advanced Healthcare Materials. Impact of surface chemistry and topography on the function of antigen presenting cells Biomaterials Science. Heparin molecularly imprinted surfaces for the attenuation of complement activation in blood Biomaterials Science. Authentication of processed meat products by peptidomic analysis using rapid ambient mass spectrometry Food Chemistry.
Materials for stem cell factories of the future. Nature Materials. EPA, V. Rapid detection of peptide markers for authentication purposes in raw and cooked meat using ambient liquid extraction surface analysis mass spectrometry. Analytical chemistry. Characterisation of a micro-plasma for ambient mass spectrometry imaging.
The Analyst. See DOI: A bio-inspired neural environment to control neurons comprising radial glia, substrate chemistry and topography Biomaterials Science. Discovery of novel materials with broad resistance to bacterial attachment using combinatorial polymer microarrays Advanced Materials. The osteogenic response of mesenchymal stem cells to an injectable PLGA bone regeneration system. Journal of the American Society for Mass Spectrometry.
Journal Of Materials Science. Materials In Medicine. Dynamics of anterior-posterior axis formation in the developing mouse embryo Nature Communications. The role of albumin and fibronectin in the adhesion of fibroblasts to plasma polymer surfaces Plasma Processes and Polymers. Polymer microarrays for high throughput discovery of biomaterials Journal of Visualised Experiments. Full-thickness characterization of plasma polymerized hexane films irradiated by an electron beam Plasma Processes and Polymers.
Combinatorial discovery of polymers resistant to bacterial attachment Nature Biotechnology. Use of imaging multivariate analysis to improve biochemical and anatomical discrimination in desorption electrospray ionisation mass spectrometry imaging.
The analyst. Neo-vascularization of the stroke cavity by implantation of human neural stem cells on vegf-releasing plga microparticles. Rapid micropatterning of cell lines and human pluripotent stem cells on elastomeric membranes. Biotechnology and bioengineering. Surface mass spectrometry of two component drug-polymer systems: novel chromatographic separation method using gentle-secondary ion mass spectrometry G-SIMS. Analytical Chemistry. Uniform cell colonization of porous 3-D scaffolds achieved using radial control of surface chemistry Acta Biomaterialia.
Dimerization of tri 4-bromophenyl benzene by aryl-aryl coupling from solution on a gold surface Journal of the American Chemical Society. Hippocampal cell response to substrates with surface chemistry gradients Acta Biomaterialia. SAHA, K. Surface-engineered substrates for improved human pluripotent stem cell culture under fully defined conditions Proceedings of the National Academy of Sciences of the United States of America. Substrate induced differentiation of human mesenchymal stem cells on hydrogels with modified surface chemistry and controlled modulus Soft Matter.
DEY, S. Enzyme-passage free culture of mouse embryonic stem cells on thermo-responsive polymer surfaces Journal of Materials Chemistry. Inkjet printing as a novel medicine formulation technique Journal of Controlled Release. High throughput methods applied in biomaterial development and discovery. High throughput surface characterization: A review of a new tool for screening prospective biomedical material arrays Journal of Drug Targeting.
Maintenance of pluripotency in human embryonic stem cells cultured on a synthetic substrate in conditioned medium Biotechnology and Bioengineering. Preparation of Caco-2 cell sheets using plasma polymerised acrylic acid as a weak boundary layer. Chemical modification of porous scaffolds using plasma polymers. Surface analysis methods: Surface Chemistry. Electron beam lithography using plasma polymerized hexane as resist Microelectronic Engineering.
Chemical patterning in biointerface science Materials Today. Bacterial attachment on optical fibre surfaces. MEI, Y. Surface analytical characterizataion of carbohydrate microarrays Surface and Interface Analysis. YANG, J. Polymer surface functionalities that control human embryoid body cell adhesion revealed by high throughput surface characterization of combinatorial material microarrays Biomaterials. Surface strategies for neuron guidance Surface Science Reports. Surface characterisation of carbohydrate microarrays Langmuir.
Quantitative XPS depth profiling of codeine loaded poly L-lactic acid films using a coronene ion sputter source Journal of Controlled Release. Partial least squares regression as a powerful tool for investigating large combinatorial polymer libraries Surface and Interface Analysis: MVA Special issue.
A high-throughput assay of cell-surface interactions using topographical and chemical gradients Advanced Materials. The support of neural stem cells transplanted into stroke-induced brain cavities by PLGA particles.
Mapping the interactions among biomaterials, adsorbed proteins, and human embryonic stem cells Advanced Materials. Nature Protocols. TODD, S. Investigation of cell-surface interactions using chemical gradients formed from plasma polymers Biomaterials.
High-energy electron beam lithography of octadecylphosphonic acid monolayers on aluminum. Controlling cell morphology on amino acid-modified cellulose Soft Matter.
Temporal evolution of an electron-free afterglow in the pulsed plasma polymerisation of acrylic acid.